About Gene List

PF3D7_1411800

Genome location: Pf3D7_14_v3:477,095..479,654(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.18 0.91
Trophozoite not expressed 0.35 0.79
Schizont not expressed 0.07 0.96
Gametocyte not expressed 0.42 0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1411800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.153 | MFS: -3.308 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILX7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532750

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 21 20 31
disruptive 17 60 41 78
missense 10 49 36 63

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 11 43 24 43
disruptive 40 141 65 125
missense 22 106 50 75

PlasmoDB Total SNPs: 124

Non-coding: 57 | Synonymous: 46 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 472 | Molecular Weight (kDa): 56.907

UniProt ID(s): Q8ILX7

PDB ID(s): None

Isoelectric Point: 9.33

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895