Product Description: mini-chromosome maintenance complex-binding protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0042555 | MCM complex |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0003682 | chromatin binding |
| Process | GO:0006261 | DNA-dependent DNA replication |
| Process | GO:0020014 | schizogony |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.14 | 0.93 |
| Trophozoite | expressed | 0.83 | 0.56 |
| Schizont | expressed | 0.54 | 0.67 |
| Gametocyte | possibly expressed | 0.24 | 0.86 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1412100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.125 | MFS: -3.083 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1030500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILX3
"Best" AlphaFill ligand hit: REA (retinoic acid, Local RMSD=11.90) with 1N4H (Global RMSD=22.27)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103417
Most Similar Human Ortholog: Q9BTE3
TM-align score: 0.74 | RMSD: 3.88
Seq Identity: 0.22 | Length: 535 / 956
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000197771 | minichromosome maintenance complex binding protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 32 | 31 | 66 |
| disruptive | 18 | 78 | 50 | 164 |
| missense | 9 | 73 | 50 | 148 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 85 | 46 | 70 |
| disruptive | 30 | 221 | 99 | 236 |
| missense | 18 | 189 | 83 | 187 |
PlasmoDB Total SNPs: 70
Non-coding: 19 | Synonymous: 25 | Nonsynonymous: 25 | Stop Codon: 1
Protein Length: 956 | Molecular Weight (kDa): 112.774
UniProt ID(s): Q8ILX3
PDB ID(s): None
Isoelectric Point: 6.31
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR019140 | Mini-chromosome maintenance complex-binding protein |
| PFam | PF09739 | Mini-chromosome maintenance complex-binding protein |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 33124706 | Depletion of the mini-chromosome maintenance complex binding protein allows theprogression of cytokinesis despite abnormal karyokinesis during the asexualdevelopment of Plasmodium falciparum. | Absalon S, Dvorin JD | 10.1111/cmi.13284 |
| 23322785 | The fission yeast minichromosome maintenance (MCM)-binding protein (MCM-BP),Mcb1, regulates MCM function during prereplicative complex formation in DNAreplication | Santosa V, Martha S, Hirose N, Tanaka K | 10.1074/jbc.M112.432393 |
| 22036784 | Purification and functional inactivation of the fission yeast MCM(MCM-BP)complex | Li JJ, Schnick J, Hayles J, MacNeill SA | 10.1016/j.febslet.2011.10.033 |
| 34835432 | Expansion Microscopy Reveals Plasmodium falciparum Blood-Stage Parasites UndergoAnaphase with A Chromatin Bridge in the Absence of Mini-Chromosome MaintenanceComplex Binding Protein | Liffner B, Absalon S | 10.3390/microorganisms9112306 |
| 30407533 | Genome-wide function of MCM-BP in Trypanosoma brucei DNA replication andtranscription | Kim HS | 10.1093/nar/gky1088 |
| 23451133 | MCM-BP is required for repression of life-cycle specific genes transcribed by RNApolymerase I in the mammalian infectious form of Trypanosoma brucei | Kim HS, Park SH, Gunzl A, Cross GA | 10.1371/journal.pone.0057001 |