PF3D7_1412200

Genome location: Pf3D7_14_v3:487,436..490,380(-)

Genome classification: Core

Function and Localization

Product Description: MORN repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 2.1.1.43 (Transferred entry: 2.1.1.354)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005829	cytosol

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.12	0.94
Trophozoite	not expressed	0.12	0.93
Schizont	not expressed	0.08	0.95
Gametocyte	expressed	0.44	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1412200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.103 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1030400)

Relative Growth Rate: 1.00 ± 0.19
Confidence: 4.74

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1030400)

Modification: Disrupted | RMgm-2856

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILX2

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
2.1.1.43	histone-lysine N-methyltransferase	BRENDA SOAP query unsuccessful

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533104

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	47	24	44
disruptive	12	106	66	176
missense	12	104	64	167

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	88	25	59
disruptive	27	264	109	217
missense	25	234	99	167

PlasmoDB Total SNPs: 124

Non-coding: 77 | Synonymous: 24 | Nonsynonymous: 23 | Stop Codon: 0

Protein Information

Protein Length: 760 | Molecular Weight (kDa): 89.335

UniProt ID(s): Q8ILX2

PDB ID(s): None

Isoelectric Point: 7.34

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF82185	N/A