Product Description: nuclear transport factor 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0044613 | nuclear pore central transport channel |
| Process | GO:0006913 | nucleocytoplasmic transport |
| Process | GO:0006606 | protein import into nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.63 | 0.34 |
| Trophozoite | expressed | 2.43 | 0.11 |
| Schizont | expressed | 0.94 | 0.55 |
| Gametocyte | expressed | 1.51 | 0.29 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1412300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.143 | MFS: -3.281 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILX1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101526
Most Similar Human Ortholog: P61970
TM-align score: 0.91 | RMSD: 0.98
Seq Identity: 0.34 | Length: 119 / 125
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000102898 | nuclear transport factor 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 74
Non-coding: 71 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 125 | Molecular Weight (kDa): 14.438
UniProt ID(s): Q8ILX1
PDB ID(s): None
Isoelectric Point: 5.61
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002075 | Nuclear transport factor 2 |
| InterPro | IPR018222 | Nuclear transport factor 2, eukaryote |
| InterPro | IPR032710 | NTF2-like domain superfamily |
| PFam | PF02136 | Nuclear transport factor 2 |
| Superfamily | SSF54427 | NTF2-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 38195464 | Characterization of a nuclear transport factor 2-like domain-containing proteinin Plasmodium berghei | Niikura M, Fukutomi T, Mitobe J, Kobayashi F | 10.1186/s12936-024-04839-9 |