Product Description: deoxyhypusine synthase
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 2.5.1.46 (Deoxyhypusine synthase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Function | GO:0034038 | deoxyhypusine synthase activity |
| Process | GO:0008612 | peptidyl-lysine modification to peptidyl-hypusine |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.27 | 0.87 |
| Trophozoite | expressed | 0.24 | 0.86 |
| Schizont | expressed | 0.03 | 0.98 |
| Gametocyte | possibly expressed | 0.28 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1412600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -3.001 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1030000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILW8
"Best" AlphaFill ligand hit: PUT (putrescine, Local RMSD=0.01) with 6XXM (Global RMSD=1.02)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.5.1.46 | deoxyhypusine synthase | FADFMNNEMGC7NADHcaldineCNI-1493guazatinespermidineputrescinehirudonineiodoacetate... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q6AY53 | Deoxyhypusine synthase | Rattus norvegicus | HOGENOM, OMA, OrthoDB | CHEMBL102939CHEMBL103613CHEMBL229457CHEMBL321347... |
| P49366 | Deoxyhypusine synthase | HOGENOM, OMA, OrthoDB | CHEMBL4470208CHEMBL4447948CHEMBL4442298CHEMBL229457... | |
| Q9GSW0 | Deoxyhypusine synthase | Plasmodium falciparum | OrthoMCL BLAST | CHEMBL229457 |
Ortholog Group (OrthoMCL): OG6_101093
Most Similar Human Ortholog: M0R1T2
TM-align score: 0.98 | RMSD: 0.77
Seq Identity: 0.61 | Length: 138 / 496
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000095059 | deoxyhypusine synthase |
| ENSG00000285589 | novel transcript |
Protein Length: 496 | Molecular Weight (kDa): 57.242
PDB ID(s): None
Isoelectric Point: 6
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002773 | Deoxyhypusine synthase |
| InterPro | IPR029035 | DHS-like NAD/FAD-binding domain superfamily |
| PFam | PF01916 | Deoxyhypusine synthase |
| Superfamily | SSF52467 | DHS-like NAD/FAD-binding domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 20 | 13 | 37 |
| disruptive | 6 | 42 | 25 | 62 |
| missense | 4 | 37 | 22 | 57 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 62 | 19 | 29 |
| disruptive | 12 | 107 | 51 | 119 |
| missense | 10 | 86 | 41 | 82 |
PlasmoDB Total SNPs: 58
Non-coding: 23 | Synonymous: 25 | Nonsynonymous: 9 | Stop Codon: 1
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 17591443 | Modification of eukaryotic initiation factor 5A from Plasmodium vivax by atruncated deoxyhypusine synthase from Plasmodium falciparum: An enzyme with dualenzymatic properties. | Kaiser A, Hammels I, ..., Hoerauf A | 10.1016/j.bmc.2007.06.026 |
| 31024761 | Validation of Plasmodium falciparum deoxyhypusine synthase as an antimalarialtarget. | Aroonsri A, Posayapisit N, ..., Shaw PJ | 10.7717/peerj.6713 |
| 38395876 | Bayesian spatio-temporal analysis of malaria prevalence in children between 2 and10 years of age in Gabon | Mougeni F, Lell B, Kandala NB, Chirwa T | 10.1186/s12936-024-04880-8 |