PF3D7_1412700

Genome location: Pf3D7_14_v3:511,818..516,959(+)

Genome classification: Core

Function and Localization

Product Description: AAA family ATPase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.6.1.3 (Deleted entry)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Function	GO:0016887	ATP hydrolysis activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.21	0.90
Trophozoite	expressed	0.64	0.65
Schizont	expressed	0.06	0.96
Gametocyte	possibly expressed	0.51	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1412700

Resistome Missense Mutations: K1189T

Resistome Compounds with Missense Mutations: MMV907364

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.052 | #Insertions: 0

PlasmoGEM Phenotype: Insufficient data (Pb ortholog: PBANKA_1423200)

Relative Growth Rate: nan ± nan
Confidence: 0.10

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILW7

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.05) with 3CF1 (Global RMSD=2.10)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.6.1.3	adenosinetriphosphatase	No BRENDA inhibitors

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102053

Most Similar Human Ortholog: O15381

TM-align score: 0.62 | RMSD: 4.51

Seq Identity: 0.31 | Length: 605 / 1219

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000143748	nuclear VCP like

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	64	39	84
disruptive	85	251	125	259
missense	52	189	116	203

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	147	55	95
disruptive	141	473	200	381
missense	84	367	155	240

PlasmoDB Total SNPs: 209

Non-coding: 38 | Synonymous: 84 | Nonsynonymous: 87 | Stop Codon: 0

Protein Information

Protein Length: 1219 | Molecular Weight (kDa): 142.826

UniProt ID(s): Q8ILW7

PDB ID(s): None

Isoelectric Point: 9.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR003959	ATPase, AAA-type, core
InterPro	IPR003960	ATPase, AAA-type, conserved site
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR041569	AAA ATPase, AAA+ lid domain
PFam	PF00004	ATPase, AAA-type, core
PFam	PF17862	AAA ATPase, AAA+ lid domain
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104