PF3D7_1413000

Genome location: Pf3D7_14_v3:523,890..525,305(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.01	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.35	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1413000

Resistome Missense Mutations: V135E

Resistome Compounds with Missense Mutations: BCH070

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.385 | MFS: -2.562 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILW4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532483

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	21	10	29
disruptive	9	64	36	104
missense	9	60	33	87

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	45	23	38
disruptive	28	159	85	150
missense	18	131	74	94

PlasmoDB Total SNPs: 46

Non-coding: 0 | Synonymous: 32 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 471 | Molecular Weight (kDa): 55.05

UniProt ID(s): Q8ILW4

PDB ID(s): None

Isoelectric Point: 10.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A