About Gene List

PF3D7_1413200

Genome location: Pf3D7_14_v3:530,058..532,455(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.04 0.98
Trophozoite not expressed 0.12 0.93
Schizont possibly expressed 0.07 0.96
Gametocyte expressed 1.64 0.35

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1413200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.997 | MFS: -1.937 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILW2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533045

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 15 10 23
disruptive 8 25 25 72
missense 5 19 20 54

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 35 22 28
disruptive 20 91 54 91
missense 9 56 42 56

PlasmoDB Total SNPs: 190

Non-coding: 138 | Synonymous: 38 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 418 | Molecular Weight (kDa): 50.008

UniProt ID(s): Q8ILW2

PDB ID(s): None

Isoelectric Point: 10.67

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104