Product Description: 30S ribosomal protein S9, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005763 | mitochondrial small ribosomal subunit |
| Component | GO:0000312 | plastid small ribosomal subunit |
| Component | GO:0015935 | small ribosomal subunit |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.07 | 0.97 |
| Trophozoite | expressed | 0.69 | 0.62 |
| Schizont | possibly expressed | 0.26 | 0.84 |
| Gametocyte | expressed | 0.62 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1413400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.189 | MFS: -2.662 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILW1
"Best" AlphaFill ligand hit: LEA (pentanoic acid, Local RMSD=0.07) with 5I8S (Global RMSD=22.93)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101155
Most Similar Human Ortholog: P82933
TM-align score: 0.33 | RMSD: 3.47
Seq Identity: 0.23 | Length: 149 / 643
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000135972 | mitochondrial ribosomal protein S9 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 35 | 19 | 46 |
| disruptive | 14 | 60 | 43 | 97 |
| missense | 14 | 59 | 41 | 88 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 64 | 32 | 51 |
| disruptive | 33 | 159 | 87 | 181 |
| missense | 25 | 137 | 66 | 118 |
PlasmoDB Total SNPs: 70
Non-coding: 30 | Synonymous: 23 | Nonsynonymous: 17 | Stop Codon: 0
Protein Length: 643 | Molecular Weight (kDa): 77.15
UniProt ID(s): Q8ILW1
PDB ID(s): None
Isoelectric Point: 10.1
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000754 | Ribosomal protein S9 |
| InterPro | IPR020568 | Ribosomal protein S5 domain 2-type fold |
| PFam | PF00380 | Ribosomal protein S9 |
| Superfamily | SSF54211 | Ribosomal protein S5 domain 2-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |