Product Description: iron-sulfur cluster assembly protein SufC
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:1990229 | iron-sulfur cluster assembly complex |
| Function | GO:0016887 | ATP hydrolysis activity |
| Function | GO:0005515 | protein binding |
| Process | GO:0016226 | iron-sulfur cluster assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.26 | 0.83 |
| Schizont | expressed | 0.13 | 0.91 |
| Gametocyte | not expressed | 0.09 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1413500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.139 | MFS: -2.886 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1029200)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1031600)
Modification: Disrupted | RMgm-4781
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILW0
"Best" AlphaFill ligand hit: NOV (4-hydroxy-3-[4-hydroxy-3-(3-methylbut-2-enyl)benzamido]-8-methylcoumarin-7-yl 3-o-carbamoyl-5,5-di-c-methyl-alpha-l-lyxofuranoside, Local RMSD=0.09) with 6B89 (Global RMSD=2.77)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 19 | 12 | 15 |
| disruptive | 2 | 16 | 18 | 44 |
| missense | 2 | 16 | 17 | 42 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 40 | 9 | 24 |
| disruptive | 6 | 59 | 29 | 85 |
| missense | 6 | 45 | 27 | 63 |
PlasmoDB Total SNPs: 119
Non-coding: 107 | Synonymous: 7 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 347 | Molecular Weight (kDa): 40.273
UniProt ID(s): Q8ILW0
PDB ID(s): None
Isoelectric Point: 9.34
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003439 | ABC transporter-like |
| InterPro | IPR010230 | FeS cluster assembly SUF system, ATPase SufC |
| InterPro | IPR017871 | ABC transporter, conserved site |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00005 | ABC transporter-like |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 21722645 | Interaction between sulphur mobilisation proteins SufB and SufC: evidence for aniron-sulphur cluster biogenesis pathway in the apicoplast of Plasmodiumfalciparum. | Kumar B, Chaubey S, ..., Habib S | 10.1016/j.ijpara.2011.05.006 |
| 24086138 | The suf iron-sulfur cluster synthesis pathway is required for apicoplastmaintenance in malaria parasites. | Gisselberg JE, Dellibovi-Ragheb TA, ..., Prigge ST | 10.1371/journal.ppat.1003655 |
| 28695709 | [Fe-S] cluster assembly in the apicoplast and its indispensability in mosquitostages of the malaria parasite. | Charan M, Choudhary HH, ..., Habib S | 10.1111/febs.14159 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 35810787 | Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasmagondii has pleiotropic effects irreversibly impacting parasite viability | Renaud EA, Pamukcu S, ..., Besteiro S | 10.1016/j.jbc.2022.102243 |