PF3D7_1413600

Genome location: Pf3D7_14_v3:538,869..540,572(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.01	0.99
Trophozoite	not expressed	0.07	0.96
Schizont	expressed	0.09	0.94
Gametocyte	not expressed	0.25	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1413600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.634 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A1K5

"Best" AlphaFill ligand hit: ETX (2-ethoxyethanol, Local RMSD=0.19) with 6V4C (Global RMSD=20.08)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533537

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	26	6	31
disruptive	17	91	38	129
missense	17	89	31	114

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	39	22	50
disruptive	43	183	71	171
missense	30	159	60	122

PlasmoDB Total SNPs: 64

Non-coding: 36 | Synonymous: 12 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 523 | Molecular Weight (kDa): 63.365

UniProt ID(s): A0A144A1K5

PDB ID(s): None

Isoelectric Point: 10.4

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A