PF3D7_1413700

Genome location: Pf3D7_14_v3:540,168..546,533(-)

Genome classification: Core

Function and Localization

Product Description: DET1 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.58	0.79
Trophozoite	expressed	0.26	0.85
Schizont	expressed	0.74	0.65
Gametocyte	not expressed	0.15	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1413700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.229 | MFS: -2.746 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILV8

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.67) with 6JWQ (Global RMSD=40.44)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533687

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	60	30	74
disruptive	55	195	105	261
missense	27	166	98	235

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	128	50	93
disruptive	114	412	206	374
missense	54	350	173	288

PlasmoDB Total SNPs: 440

Non-coding: 236 | Synonymous: 68 | Nonsynonymous: 134 | Stop Codon: 2

Protein Information

Protein Length: 1213 | Molecular Weight (kDa): 145.003

UniProt ID(s): Q8ILV8

PDB ID(s): None

Isoelectric Point: 9.37

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019138	De-etiolated protein 1, Det1
PFam	N/A	N/A
Superfamily	N/A	N/A