PF3D7_1413900

Genome location: Pf3D7_14_v3:550,913..553,649(+)

Genome classification: Core

Function and Localization

Product Description: DnaJ protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Function	GO:0051082	unfolded protein binding
Process	GO:0051085	chaperone cofactor-dependent protein refolding
Process	GO:0042026	protein refolding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.06	0.97
Trophozoite	expressed	0.09	0.94
Schizont	expressed	0.04	0.97
Gametocyte	expressed	0.07	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1413900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.94 | MFS: -2.235 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1028800)

Relative Growth Rate: 0.21 ± 0.17
Confidence: 4.90

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILV6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130908

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	23	15	31
disruptive	1	4	6	14
missense	1	4	6	11

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	47	21	31
disruptive	3	20	26	71
missense	2	17	17	50

PlasmoDB Total SNPs: 84

Non-coding: 78 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 381 | Molecular Weight (kDa): 45.239

UniProt ID(s): Q8ILV6

PDB ID(s): None

Isoelectric Point: 5.54

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001623	DnaJ domain
InterPro	IPR018253	DnaJ domain, conserved site
InterPro	IPR036869	Chaperone J-domain superfamily
PFam	PF00226	DnaJ domain
Superfamily	SSF46565	Chaperone J-domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094