PF3D7_1414100

Genome location: Pf3D7_14_v3:557,487..562,812(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.44	0.78
Trophozoite	expressed	0.23	0.86
Schizont	expressed	0.12	0.92
Gametocyte	expressed	0.17	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1414100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.203 | MFS: -2.875 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILV4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533605

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	47	23	47
disruptive	55	134	55	143
missense	27	100	44	118

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	82	37	76
disruptive	86	276	116	296
missense	41	213	91	180

PlasmoDB Total SNPs: 421

Non-coding: 303 | Synonymous: 69 | Nonsynonymous: 48 | Stop Codon: 1

Protein Information

Protein Length: 743 | Molecular Weight (kDa): 85.74

UniProt ID(s): Q8ILV4

PDB ID(s): None

Isoelectric Point: 9.39

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR025829	Zinc knuckle CX2CX3GHX4C
InterPro	IPR033489	E3 ubiquitin-protein ligase RBBP6 family
PFam	PF13696	Zinc knuckle CX2CX3GHX4C
Superfamily	SSF57850	N/A