Product Description: 60S ribosomal protein L10, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0098808 | mRNA cap binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0000027 | ribosomal large subunit assembly |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.28 | 0.45 |
| Trophozoite | expressed | 1.67 | 0.29 |
| Schizont | expressed | 0.49 | 0.70 |
| Gametocyte | expressed | 1.02 | 0.48 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1414300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.861 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILV2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100701
Most Similar Human Ortholog: X1WI28
TM-align score: 0.99 | RMSD: 0.44
Seq Identity: 0.72 | Length: 200 / 219
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000147403 | ribosomal protein L10 |
| ENSG00000165496 | ribosomal protein L10 like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 14 | 3 | 11 |
| disruptive | 0 | 2 | 2 | 12 |
| missense | 0 | 2 | 1 | 11 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 25 | 5 | 10 |
| disruptive | 1 | 6 | 16 | 42 |
| missense | 1 | 5 | 14 | 36 |
PlasmoDB Total SNPs: 60
Non-coding: 45 | Synonymous: 12 | Nonsynonymous: 1 | Stop Codon: 2
Protein Length: 219 | Molecular Weight (kDa): 25.216
UniProt ID(s): Q8ILV2
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 10.51
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001197 | Ribosomal protein L10e |
| InterPro | IPR016180 | Ribosomal protein L10e/L16 |
| InterPro | IPR018255 | Ribosomal protein L10e, conserved site |
| InterPro | IPR036920 | Ribosomal protein L10e/L16 superfamily |
| PFam | PF00252 | Ribosomal protein L10e/L16 |
| Superfamily | SSF54686 | Ribosomal protein L10e/L16 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |