PF3D7_1414500 (ABCk2)

Genome location: Pf3D7_14_v3:577,208..589,915(-)

Genome classification: Core

Function and Localization

Product Description: atypical protein kinase, ABC-1 family, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 1.14.13.- (With NADH or NADPH as one donor, and incorporation of one atom of oxygen.)

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1414500

Resistome Missense Mutations: N2685K

Resistome Compounds with Missense Mutations: Halofuginone

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.192 | MFS: -2.721 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1030600)

Modification: Disrupted | RMgm-4057

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_112296

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 777

Non-coding: 363 | Synonymous: 182 | Nonsynonymous: 232 | Stop Codon: 0

Protein Information

Protein Length: 2758 | Molecular Weight (kDa): 326.041

UniProt ID(s): A0A144A1E4

PDB ID(s): None

Isoelectric Point: 9.39

Protein Domain Annotations: