Product Description: small nuclear ribonucleoprotein-associated protein B, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005685 | U1 snRNP |
| Component | GO:0005686 | U2 snRNP |
| Component | GO:0071004 | U2-type prespliceosome |
| Component | GO:0005687 | U4 snRNP |
| Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Component | GO:0005682 | U5 snRNP |
| Component | GO:0071013 | catalytic step 2 spliceosome |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Component | GO:0005681 | spliceosomal complex |
| Process | GO:0008380 | RNA splicing |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.29 | 0.82 |
| Schizont | expressed | 0.04 | 0.97 |
| Gametocyte | expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1414800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -3.272 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILU8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101868
Most Similar Human Ortholog: S4R3P3
TM-align score: 0.78 | RMSD: 2.14
Seq Identity: 0.34 | Length: 67 / 201
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000125835 | small nuclear ribonucleoprotein polypeptides B and B1 |
| ENSG00000128739 | small nuclear ribonucleoprotein polypeptide N |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 98
Non-coding: 86 | Synonymous: 3 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 201 | Molecular Weight (kDa): 22.332
UniProt ID(s): Q8ILU8
PDB ID(s): None
Isoelectric Point: 10.86
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001163 | LSM domain, eukaryotic/archaea-type |
| InterPro | IPR010920 | LSM domain superfamily |
| PFam | PF01423 | LSM domain, eukaryotic/archaea-type |
| Superfamily | SSF50182 | LSM domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 20885950 | Characterisation of the SUMO-like domains of Schizosaccharomyces pombe Rad60 | Boyd LK, Mercer B, ..., Watts FZ | 10.1371/journal.pone.0013009 |