PF3D7_1415100

Genome location: Pf3D7_14_v3:608,580..611,484(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	possibly expressed	0.06	0.97
Schizont	expressed	0.51	0.75
Gametocyte	expressed	0.47	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1415100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.001 | #Insertions: 2

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1027600)

Relative Growth Rate: 0.93 ± 0.06
Confidence: 7.00

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1027600)

Modification: Disrupted | RMgm-2846

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILU5

"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=2.49) with 1ON8 (Global RMSD=18.73)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_148532

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	24	21	35
disruptive	15	55	40	73
missense	15	55	38	68

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	55	25	32
disruptive	24	120	54	90
missense	21	111	49	74

PlasmoDB Total SNPs: 143

Non-coding: 103 | Synonymous: 25 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 590 | Molecular Weight (kDa): 69.554

UniProt ID(s): Q8ILU5

PDB ID(s): None

Isoelectric Point: 9.39

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A