Product Description: RNA-binding protein Nova-1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003729 | mRNA binding |
| Process | GO:0010468 | regulation of gene expression |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.09 | 0.94 |
| Schizont | expressed | 0.15 | 0.89 |
| Gametocyte | expressed | 0.17 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1415300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.89 | MFS: -2.977 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILU3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103746
Most Similar Human Ortholog: G8JLA5
TM-align score: 0.67 | RMSD: 2.64
Seq Identity: 0.31 | Length: 88 / 337
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000104967 | NOVA alternative splicing regulator 2 |
| ENSG00000139910 | NOVA alternative splicing regulator 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 15 | 7 | 14 |
| disruptive | 2 | 8 | 5 | 40 |
| missense | 2 | 8 | 5 | 28 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 34 | 11 | 21 |
| disruptive | 2 | 42 | 31 | 67 |
| missense | 2 | 34 | 22 | 51 |
PlasmoDB Total SNPs: 139
Non-coding: 129 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 1
Protein Length: 337 | Molecular Weight (kDa): 37.504
UniProt ID(s): Q8ILU3
PDB ID(s): None
Isoelectric Point: 9.86
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004087 | K Homology domain |
| InterPro | IPR004088 | K Homology domain, type 1 |
| InterPro | IPR036612 | K Homology domain, type 1 superfamily |
| PFam | PF00013 | K Homology domain, type 1 |
| Superfamily | SSF54791 | K Homology domain, type 1 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |