PF3D7_1415400

Genome location: Pf3D7_14_v3:617,813..623,560(+)

Genome classification: Core

Function and Localization

Product Description: Btz domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0003729	mRNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.15	0.93
Trophozoite	expressed	0.74	0.60
Schizont	possibly expressed	0.14	0.91
Gametocyte	not expressed	0.67	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1415400

Resistome Missense Mutations: M400I, R456P

Resistome Compounds with Missense Mutations: Cipargamin/KAE609/NITD609, Desoxyepothilone B

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.199 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1027300)

Modification: Disrupted | RMgm-2845

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILU2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533656

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	30	49	40	94
disruptive	99	230	144	296
missense	62	170	121	229

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	39	116	66	84
disruptive	129	478	214	438
missense	78	365	158	284

PlasmoDB Total SNPs: 276

Non-coding: 64 | Synonymous: 104 | Nonsynonymous: 107 | Stop Codon: 1

Protein Information

Protein Length: 1474 | Molecular Weight (kDa): 178.501

UniProt ID(s): Q8ILU2

PDB ID(s): None

Isoelectric Point: 9.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR018545	Btz domain
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
27381095	The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum.	Bunnik EM, Batugedara G, ..., Le Roch KG	10.1186/s13059-016-1014-0