Product Description: serine palmitoyltransferase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: 2.3.1.50 (Serine C-palmitoyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0002179 | homodimeric serine palmitoyltransferase complex |
| Component | GO:0016020 | membrane |
| Component | GO:0017059 | serine C-palmitoyltransferase complex |
| Function | GO:0004758 | serine C-palmitoyltransferase activity |
| Process | GO:0046513 | ceramide biosynthetic process |
| Process | GO:0030148 | sphingolipid biosynthetic process |
| Process | GO:0046512 | sphingosine biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.01 | 0.99 |
| Trophozoite | possibly expressed | 0.02 | 0.99 |
| Schizont | expressed | 0.07 | 0.95 |
| Gametocyte | expressed | 0.26 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1415700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.129 | MFS: -2.976 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILT9
"Best" AlphaFill ligand hit: PLP (pyridoxal-5'-phosphate, Local RMSD=0.24) with 3TQX (Global RMSD=1.87)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.3.1.50 | serine C-palmitoyltransferase | myrocincysteinemyriocinL-alaninethreoninelipoxamycinpalmitoyl-CoAL-Cycloserinesulfamisterinpalmitoyl CoAO-phosphoserinethermozymocidin... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| O15270 | Serine palmitoyltransferase 2 | Homo sapiens | OrthoDB | CHEMBL1241090CHEMBL4226297CHEMBL4229253CHEMBL4226045... |
| O15269 | Serine palmitoyltransferase 1 | Homo sapiens | OrthoDB | CHEMBL1241090CHEMBL4541898CHEMBL4584997CHEMBL4541898... |
| P22557 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial | OrthoDB | US11479532, Compound SZ10TA40US11479532, Compound SZ12TA42 |
Ortholog Group (OrthoMCL): OG6_100700
Most Similar Human Ortholog: O15270
TM-align score: 0.70 | RMSD: 3.17
Seq Identity: 0.27 | Length: 429 / 572
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100596 | serine palmitoyltransferase long chain base subunit 2 |
| ENSG00000172296 | serine palmitoyltransferase long chain base subunit 3 |
Protein Length: 572 | Molecular Weight (kDa): 65.533
UniProt ID(s): Q8ILT9
PDB ID(s): None
Isoelectric Point: 9.26
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001917 | Aminotransferase, class-II, pyridoxal-phosphate binding site |
| InterPro | IPR004839 | Aminotransferase, class I/classII |
| InterPro | IPR015424 | Pyridoxal phosphate-dependent transferase |
| PFam | PF00155 | Aminotransferase, class I/classII |
| Superfamily | SSF53383 | Pyridoxal phosphate-dependent transferase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 33 | 13 | 39 |
| disruptive | 1 | 12 | 9 | 47 |
| missense | 1 | 12 | 9 | 39 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 60 | 31 | 37 |
| disruptive | 2 | 56 | 35 | 108 |
| missense | 1 | 38 | 29 | 69 |
PlasmoDB Total SNPs: 123
Non-coding: 101 | Synonymous: 20 | Nonsynonymous: 2 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 28578314 | Functional and phylogenetic evidence of a bacterial origin for the first enzymein sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites. | Mina JG, Thye JK, ..., Denny PW | 10.1074/jbc.M117.792374 |