Product Description: zinc finger protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000812 | Swr1 complex |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0042826 | histone deacetylase binding |
| Function | GO:0031491 | nucleosome binding |
| Process | GO:0043486 | histone exchange |
| Process | GO:0031063 | regulation of histone deacetylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.05 | 0.97 |
| Trophozoite | expressed | 0.07 | 0.95 |
| Schizont | possibly expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1415900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.138 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILT7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 6 | 3 | 9 |
| disruptive | 2 | 6 | 5 | 15 |
| missense | 2 | 6 | 4 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 13 | 2 | 18 |
| disruptive | 2 | 19 | 19 | 26 |
| missense | 2 | 14 | 16 | 15 |
PlasmoDB Total SNPs: 47
Non-coding: 44 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 146 | Molecular Weight (kDa): 16.862
UniProt ID(s): Q8ILT7
PDB ID(s): None
Isoelectric Point: 9.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007529 | Zinc finger, HIT-type |
| InterPro | IPR039723 | Vps71/ZNHIT1 |
| PFam | PF04438 | Zinc finger, HIT-type |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |