Product Description: protein SEY1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: 3.6.5.- (Acting on GTP; involved in cellular and subcellular movement.)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005783 | endoplasmic reticulum |
| Function | GO:0005525 | GTP binding |
| Function | GO:0003924 | GTPase activity |
| Process | GO:0016320 | endoplasmic reticulum membrane fusion |
| Process | GO:0007029 | endoplasmic reticulum organization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.64 | 0.70 |
| Trophozoite | expressed | 0.37 | 0.77 |
| Schizont | expressed | 0.55 | 0.67 |
| Gametocyte | expressed | 0.22 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1416100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.143 | MFS: -3.264 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILT5
"Best" AlphaFill ligand hit: 5GP (guanosine-5'-monophosphate, Local RMSD=2.84) with 2B8W (Global RMSD=5.64)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.5.- | Ex: heterotrimeric G-protein GTPase | GDPGTPITPNEMEDTANO3-PlexANH4ClppGppstatinCCG-977Rap1Gap... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 58 | 44 | 70 |
| disruptive | 30 | 87 | 65 | 144 |
| missense | 11 | 77 | 55 | 117 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 111 | 40 | 67 |
| disruptive | 52 | 204 | 110 | 213 |
| missense | 26 | 157 | 86 | 138 |
PlasmoDB Total SNPs: 193
Non-coding: 116 | Synonymous: 53 | Nonsynonymous: 24 | Stop Codon: 0
Protein Length: 937 | Molecular Weight (kDa): 110.61
UniProt ID(s): A0A144A1B3, Q8ILT5
PDB ID(s): None
Isoelectric Point: 7.55
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008803 | RHD3/Sey1 |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF05879 | RHD3/Sey1 |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 26370501 | Structures of the yeast dynamin-like GTPase Sey1p provide insight into homotypicER fusion | Yan L, Sun S, ..., Lou Z | 10.1083/jcb.201502078 |
| 36650056 | Protein S-palmitoylation regulates different stages of meiosis inSchizosaccharomyces pombe | Pham TV, Hsiao WY, ..., Wang SW | 10.26508/lsa.202201755 |
| 24152736 | ER-associated SNAREs and Sey1p mediate nuclear fusion at two distinct stepsduring yeast mating | Rogers JV, Arlow T, ..., Rose MD | 10.1091/mbc.E13-08-0441 |
| 26216899 | SNAREs support atlastin-mediated homotypic ER fusion in Saccharomyces cerevisiae | Lee M, Ko YJ, ..., Jun Y | 10.1083/jcb.201501043 |