PF3D7_1416400

Genome location: Pf3D7_14_v3:661,098..665,295(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.21	0.89
Trophozoite	not expressed	0.05	0.97
Schizont	not expressed	0.04	0.97
Gametocyte	possibly expressed	0.95	0.54

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1416400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.168 | MFS: -2.65 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1026300)

Relative Growth Rate: 0.97 ± 0.15
Confidence: 5.21

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1026300)

Modification: Disrupted | RMgm-2842

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILT2

"Best" AlphaFill ligand hit: EDT ({[-(bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetic acid, Local RMSD=2.41) with 3L7K (Global RMSD=22.58)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532339

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	40	29	42
disruptive	12	61	38	109
missense	11	59	37	103

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	83	28	49
disruptive	24	136	68	157
missense	18	123	61	134

PlasmoDB Total SNPs: 284

Non-coding: 219 | Synonymous: 46 | Nonsynonymous: 18 | Stop Codon: 1

Protein Information

Protein Length: 646 | Molecular Weight (kDa): 77.218

UniProt ID(s): Q8ILT2

PDB ID(s): None

Isoelectric Point: 9.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A