PF3D7_1416600

Genome location: Pf3D7_14_v3:669,374..679,741(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.12	0.94
Schizont	not expressed	0.29	0.85
Gametocyte	not expressed	0.80	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1416600

Resistome Missense Mutations: M2760I

Resistome Compounds with Missense Mutations: Lopinavir

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.037 | #Insertions: 12

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532982

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	22	135	90	201
disruptive	86	461	284	651
missense	73	438	269	593

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	38	278	145	211
disruptive	190	950	471	758
missense	142	848	427	620

PlasmoDB Total SNPs: 317

Non-coding: 83 | Synonymous: 113 | Nonsynonymous: 120 | Stop Codon: 1

Protein Information

Protein Length: 3026 | Molecular Weight (kDa): 357.636

UniProt ID(s): Q8ILS9

PDB ID(s): None

Isoelectric Point: 9.31

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A