PF3D7_1416700

Genome location: Pf3D7_14_v3:680,612..682,264(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	1.00
Trophozoite	no data	0.01	0.99
Schizont	no data	0.00	1.00
Gametocyte	no data	0.54	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1416700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.363 | MFS: -2.657 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1026000)

Relative Growth Rate: 1.00 ± 0.14
Confidence: 5.35

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1026000)

Modification: Disrupted | RMgm-2840

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3H6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215377

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	8	4	13
disruptive	3	22	7	22
missense	3	21	7	21

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	20	7	8
disruptive	10	30	20	27
missense	10	27	18	21

PlasmoDB Total SNPs: 147

Non-coding: 140 | Synonymous: 3 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 132 | Molecular Weight (kDa): 16.077

UniProt ID(s): C6S3H6

PDB ID(s): None

Isoelectric Point: 8.33

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A