Product Description: prefoldin subunit 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Function | GO:0044183 | protein folding chaperone |
| Process | GO:0006457 | protein folding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.39 | 0.76 |
| Schizont | expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 0.30 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1416900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.554 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILS7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102034
Most Similar Human Ortholog: Q9UHV9
TM-align score: 0.70 | RMSD: 1.78
Seq Identity: 0.33 | Length: 110 / 147
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000143256 | prefoldin subunit 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 13 | 5 | 11 |
| disruptive | 3 | 10 | 8 | 24 |
| missense | 2 | 10 | 8 | 23 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 23 | 6 | 12 |
| disruptive | 5 | 37 | 15 | 37 |
| missense | 4 | 33 | 14 | 28 |
PlasmoDB Total SNPs: 43
Non-coding: 32 | Synonymous: 5 | Nonsynonymous: 3 | Stop Codon: 3
Protein Length: 147 | Molecular Weight (kDa): 16.653
UniProt ID(s): Q8ILS7
PDB ID(s): None
Isoelectric Point: 4.81
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002777 | Prefoldin beta-like |
| InterPro | IPR027235 | Prefoldin subunit 2 |
| PFam | PF01920 | Prefoldin beta-like |
| Superfamily | SSF46579 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |