Product Description: inner membrane complex protein 1l
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0070258 | inner membrane pellicle complex |
| Function | GO:0005509 | calcium ion binding |
| Function | GO:0008289 | lipid binding |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | not expressed | 0.01 | 0.99 |
| Schizont | not expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.16 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1417000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.778 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1028100)
Modification: Tagged | RMgm-4496
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILS6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 15 | 11 | 35 |
| disruptive | 11 | 62 | 25 | 72 |
| missense | 9 | 60 | 25 | 71 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 41 | 16 | 30 |
| disruptive | 29 | 110 | 66 | 120 |
| missense | 25 | 107 | 57 | 94 |
PlasmoDB Total SNPs: 38
Non-coding: 0 | Synonymous: 15 | Nonsynonymous: 23 | Stop Codon: 0
Protein Length: 382 | Molecular Weight (kDa): 45.514
UniProt ID(s): Q8ILS6
PDB ID(s): None
Isoelectric Point: 6
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30599160 | Inner membrane complex 1l protein of Plasmodium falciparum links membrane lipidswith cytoskeletal element 'actin' and its associated motor 'myosin'. | Kumar V, Behl A, ..., Hora R | 10.1016/j.ijbiomac.2018.12.239 |