PF3D7_1417300 (ATG4)

Genome location: Pf3D7_14_v3:708,755..713,627(+)

Genome classification: Core

Function and Localization

Product Description: cysteine protease ATG4, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.4.22.- (Cysteine endopeptidases.)

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1417300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.802 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILS3

"Best" AlphaFill ligand hit: COA (coenzyme a, Local RMSD=0.84) with 5W40 (Global RMSD=12.34)

BRENDA EC Inhibitors:

Orthology to BindingDB Entries:

Orthology Information

Ortholog Group (OrthoMCL): OG6_100501

Most Similar Human Ortholog: C9J1C1

TM-align score: 0.84 | RMSD: 1.80

Seq Identity: 0.21 | Length: 66 / 1124

All Human Orthologs (OrthoMCL):

Protein Information

Protein Length: 1124 | Molecular Weight (kDa): 132.716

UniProt ID(s): Q8ILS3

PDB ID(s): None

Isoelectric Point: 9.77

Protein Domain Annotations:

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 186

Non-coding: 63 | Synonymous: 80 | Nonsynonymous: 43 | Stop Codon: 0