About Gene List

PF3D7_1417600

Genome location: Pf3D7_14_v3:730,017..746,011(-)

Genome classification: Core

Function and Localization

Product Description: ookinete surface and oocyst capsule protein OSCP, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0042603 capsule
Component GO:0009986 cell surface
Component GO:0005887 integral component of plasma membrane
Function GO:0038023 signaling receptor activity
Process GO:0048870 cell motility

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.99 0.27
Trophozoite expressed 1.74 0.26
Schizont expressed 1.36 0.37
Gametocyte expressed 1.60 0.29

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1417600

Resistome Missense Mutations: R863I

Resistome Compounds with Missense Mutations: PS-3

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.743 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1025100)

Modification: Disrupted | RMgm-5045

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_123314

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 45 219 111 215
disruptive 220 738 409 866
missense 125 590 352 737

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 86 369 166 299
disruptive 380 1436 583 1158
missense 212 1115 493 908

PlasmoDB Total SNPs: 790

Non-coding: 183 | Synonymous: 354 | Nonsynonymous: 251 | Stop Codon: 2

Protein Information

Protein Length: 4662 | Molecular Weight (kDa): 548.869

UniProt ID(s): A0A144A1P7, Q8ILR9

PDB ID(s): None

Isoelectric Point: 9.06

Protein Domain Annotations:

Source Family ID Description
InterPro IPR017241 Toll-like receptor
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
34289894 Role of Plasmodium berghei ookinete surface and oocyst capsule protein, a noveloocyst capsule-associated protein, in ookinete motility. Nakayama K, Kimura Y, ..., Ikadai H 10.1186/s13071-021-04868-2