Product Description: ookinete surface and oocyst capsule protein OSCP, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0042603 | capsule |
Component | GO:0009986 | cell surface |
Component | GO:0005887 | integral component of plasma membrane |
Function | GO:0038023 | signaling receptor activity |
Process | GO:0048870 | cell motility |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 1.99 | 0.27 |
Trophozoite | expressed | 1.74 | 0.26 |
Schizont | expressed | 1.36 | 0.37 |
Gametocyte | expressed | 1.60 | 0.29 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1417600
Resistome Missense Mutations: R863I
Resistome Compounds with Missense Mutations: PS-3
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.743 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1025100)
Modification: Disrupted | RMgm-5045
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 45 | 219 | 111 | 215 |
disruptive | 220 | 738 | 409 | 866 |
missense | 125 | 590 | 352 | 737 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 86 | 369 | 166 | 299 |
disruptive | 380 | 1436 | 583 | 1158 |
missense | 212 | 1115 | 493 | 908 |
PlasmoDB Total SNPs: 790
Non-coding: 183 | Synonymous: 354 | Nonsynonymous: 251 | Stop Codon: 2
Protein Length: 4662 | Molecular Weight (kDa): 548.869
UniProt ID(s): A0A144A1P7, Q8ILR9
PDB ID(s): None
Isoelectric Point: 9.06
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR017241 | Toll-like receptor |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
34289894 | Role of Plasmodium berghei ookinete surface and oocyst capsule protein, a noveloocyst capsule-associated protein, in ookinete motility. | Nakayama K, Kimura Y, ..., Ikadai H | 10.1186/s13071-021-04868-2 |