PF3D7_1417600

Genome location: Pf3D7_14_v3:730,017..746,011(-)

Genome classification: Core

Function and Localization

Product Description: ookinete surface and oocyst capsule protein OSCP, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0042603	capsule
Component	GO:0009986	cell surface
Component	GO:0005887	integral component of plasma membrane
Function	GO:0038023	signaling receptor activity
Process	GO:0048870	cell motility

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.99	0.27
Trophozoite	expressed	1.74	0.26
Schizont	expressed	1.36	0.37
Gametocyte	expressed	1.60	0.29

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1417600

Resistome Missense Mutations: R863I

Resistome Compounds with Missense Mutations: PS-3

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.743 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1025100)

Modification: Disrupted | RMgm-5045

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_123314

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	45	219	111	215
disruptive	220	738	409	866
missense	125	590	352	737

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	86	369	166	299
disruptive	380	1436	583	1158
missense	212	1115	493	908

PlasmoDB Total SNPs: 790

Non-coding: 183 | Synonymous: 354 | Nonsynonymous: 251 | Stop Codon: 2

Protein Information

Protein Length: 4662 | Molecular Weight (kDa): 548.869

UniProt ID(s): A0A144A1P7, Q8ILR9

PDB ID(s): None

Isoelectric Point: 9.06

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR017241	Toll-like receptor
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
34289894	Role of Plasmodium berghei ookinete surface and oocyst capsule protein, a noveloocyst capsule-associated protein, in ookinete motility.	Nakayama K, Kimura Y, ..., Ikadai H	10.1186/s13071-021-04868-2