PF3D7_1417900 (ATPTG9)

Genome location: Pf3D7_14_v3:756,645..758,888(-)

Genome classification: Core

Function and Localization

Product Description: ATP synthase-associated protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.03	0.98
Trophozoite	no data	0.35	0.78
Schizont	no data	0.05	0.96
Gametocyte	no data	0.39	0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1417900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.213 | MFS: -2.402 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1024800)

Relative Growth Rate: 0.90 ± 0.14
Confidence: 5.36

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1024800)

Modification: Tagged | RMgm-4963

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3H7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_149566

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	10	2	8
disruptive	2	9	7	23
missense	2	9	7	22

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	16	5	4
disruptive	4	26	20	38
missense	4	23	20	27

PlasmoDB Total SNPs: 199

Non-coding: 196 | Synonymous: 1 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 144 | Molecular Weight (kDa): 16.831

UniProt ID(s): C6S3H7

PDB ID(s): None

Isoelectric Point: 8.48

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21