Product Description: ubiquitin fusion degradation protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex |
| Function | GO:0031593 | polyubiquitin modification-dependent protein binding |
| Function | GO:0043130 | ubiquitin binding |
| Process | GO:0071712 | ER-associated misfolded protein catabolic process |
| Process | GO:0030433 | ubiquitin-dependent ERAD pathway |
| Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.15 | 0.90 |
| Schizont | expressed | 0.15 | 0.90 |
| Gametocyte | possibly expressed | 0.23 | 0.86 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1418000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.195 | MFS: -2.557 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILR6
"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=1.05) with 6JWR (Global RMSD=21.73)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101567
Most Similar Human Ortholog: C9J7C8
TM-align score: 0.89 | RMSD: 1.25
Seq Identity: 0.48 | Length: 69 / 282
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000070010 | ubiquitin recognition factor in ER associated degradation 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 16 | 15 | 20 |
| disruptive | 1 | 6 | 4 | 25 |
| missense | 1 | 6 | 4 | 24 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 30 | 21 | 25 |
| disruptive | 2 | 34 | 16 | 44 |
| missense | 2 | 28 | 14 | 32 |
PlasmoDB Total SNPs: 156
Non-coding: 151 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 282 | Molecular Weight (kDa): 32.478
UniProt ID(s): Q8ILR6
PDB ID(s): None
Isoelectric Point: 6.6
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004854 | Ubiquitin fusion degradation protein Ufd1-like |
| InterPro | IPR029067 | CDC48 domain 2-like superfamily |
| PFam | PF03152 | Ubiquitin fusion degradation protein Ufd1-like |
| Superfamily | SSF54585 | CDC48 domain 2-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |