About Gene List

PF3D7_1418100 (LISP1)

Genome location: Pf3D7_14_v3:762,614..773,407(-)

Genome classification: Core

Function and Localization

Product Description: liver specific protein 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020005 symbiont-containing vacuole membrane
Process GO:0035891 exit from host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite not expressed 0.03 0.98
Schizont not expressed 0.01 0.99
Gametocyte not expressed 0.06 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1418100

Resistome Missense Mutations: K2805N

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.62 | #Insertions: 21

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1024600)

  • Relative Growth Rate: 0.98 ± 0.15
  • Confidence: 5.20

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1024600)

Modification: Disrupted | RMgm-4943

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532375

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 29 162 74 198
disruptive 128 337 190 495
missense 92 283 168 408

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 52 264 138 269
disruptive 212 725 338 748
missense 144 560 284 549

PlasmoDB Total SNPs: 345

Non-coding: 0 | Synonymous: 202 | Nonsynonymous: 142 | Stop Codon: 1

Protein Information

Protein Length: 3597 | Molecular Weight (kDa): 423.709

UniProt ID(s): Q8ILR5

PDB ID(s): None

Isoelectric Point: 6.31

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
19435743 ESG: extended similarity group method for automated protein function prediction. Chitale M, Hawkins T, Park C, Kihara D 10.1093/bioinformatics/btp309
19438514 LISP1 is important for the egress of Plasmodium berghei parasites from livercells. Ishino T, Boisson B, ..., Baldacci P 10.1111/j.1462-5822.2009.01333.x