About Gene List

PF3D7_1418200

Genome location: Pf3D7_14_v3:775,121..776,382(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.11 0.95
Trophozoite not expressed 0.52 0.70
Schizont not expressed 0.17 0.89
Gametocyte not expressed 0.26 0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1418200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.185 | MFS: -3.104 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1024500)

  • Relative Growth Rate: 0.14 ± 0.09
  • Confidence: 6.10

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILR4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533692

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 5 7 7
disruptive 3 34 14 25
missense 1 32 14 24

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 10 6 5
disruptive 8 53 25 45
missense 5 47 24 38

PlasmoDB Total SNPs: 59

Non-coding: 47 | Synonymous: 6 | Nonsynonymous: 5 | Stop Codon: 1

Protein Information

Protein Length: 166 | Molecular Weight (kDa): 19.217

UniProt ID(s): Q8ILR4

PDB ID(s): None

Isoelectric Point: 4.57

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108