PF3D7_1418300

Genome location: Pf3D7_14_v3:776,390..777,202(+)

Genome classification: Core

Function and Localization

Product Description: calmodulin, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0005509	calcium ion binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.01	1.00
Trophozoite	expressed	0.03	0.98
Schizont	expressed	0.01	0.99
Gametocyte	expressed	0.03	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1418300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.176 | MFS: -3.039 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILR3

"Best" AlphaFill ligand hit: MPO (3[n-morpholino]propane sulfonic acid, Local RMSD=0.08) with 5I0I (Global RMSD=4.51)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532893

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	10	8	7
disruptive	2	9	4	23
missense	2	9	4	20

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	20	6	9
disruptive	4	20	11	29
missense	3	18	8	21

PlasmoDB Total SNPs: 33

Non-coding: 24 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 136 | Molecular Weight (kDa): 15.637

UniProt ID(s): Q8ILR3

PDB ID(s): None

Isoelectric Point: 9.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002048	EF-hand domain
InterPro	IPR011992	EF-hand domain pair
PFam	PF13499	EF-hand domain
Superfamily	SSF47473	EF-hand domain pair