Product Description: thioredoxin-like protein, putative
SignalP Peptide: MMKKLILFVLFQVYIICIKNVKS
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.09 | 0.96 |
| Trophozoite | expressed | 0.61 | 0.65 |
| Schizont | possibly expressed | 0.05 | 0.97 |
| Gametocyte | not expressed | 0.28 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1419200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.311 | MFS: -3.438 | #Insertions: 1
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1024000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILQ8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100836
Most Similar Human Ortholog: Q5VZ03
TM-align score: 0.72 | RMSD: 2.96
Seq Identity: 0.16 | Length: 134 / 671
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000130045 | nucleoredoxin like 2 |
| ENSG00000167693 | nucleoredoxin |
| ENSG00000280563 | nucleoredoxin |
| ENSG00000281300 | nucleoredoxin |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 39 | 20 | 44 |
| disruptive | 25 | 63 | 36 | 92 |
| missense | 16 | 56 | 33 | 81 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 73 | 30 | 61 |
| disruptive | 37 | 148 | 81 | 166 |
| missense | 24 | 117 | 71 | 130 |
PlasmoDB Total SNPs: 159
Non-coding: 94 | Synonymous: 29 | Nonsynonymous: 36 | Stop Codon: 0
Protein Length: 671 | Molecular Weight (kDa): 80.239
UniProt ID(s): Q8ILQ8
PDB ID(s): None
Isoelectric Point: 10.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR012336 | Thioredoxin-like fold |
| InterPro | IPR036249 | Thioredoxin-like superfamily |
| PFam | PF13905 | Thioredoxin-like fold |
| Superfamily | SSF52833 | Thioredoxin-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 29470517 | Two essential Thioredoxins mediate apicoplast biogenesis, protein import, andgene expression in Toxoplasma gondii. | Biddau M, Bouchut A, ..., Sheiner L | 10.1371/journal.ppat.1006836 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 18586952 | A thioredoxin family protein of the apicoplast periphery identifies abundantcandidate transport vesicles in Toxoplasma gondii | DeRocher AE, Coppens I, ..., Parsons M | 10.1128/EC.00081-08 |