PF3D7_1419400

Genome location: Pf3D7_14_v3:803,869..812,354(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	1.47	0.39
Trophozoite	not expressed	1.08	0.46
Schizont	not expressed	0.39	0.77
Gametocyte	not expressed	0.83	0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1419400

Resistome Missense Mutations: D59Y

Resistome Compounds with Missense Mutations: Suloctidil

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.322 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILQ6

"Best" AlphaFill ligand hit: 1PG (2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol, Local RMSD=0.71) with 5FRE (Global RMSD=38.14)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533098

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	22	114	49	129
disruptive	71	299	194	459
missense	40	256	173	389

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	42	198	83	149
disruptive	159	677	321	618
missense	85	559	273	443

PlasmoDB Total SNPs: 423

Non-coding: 189 | Synonymous: 140 | Nonsynonymous: 94 | Stop Codon: 0

Protein Information

Protein Length: 2201 | Molecular Weight (kDa): 262.309

UniProt ID(s): Q8ILQ6

PDB ID(s): None

Isoelectric Point: 6.75

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A