Product Description: eukaryotic translation initiation factor 3 subunit H, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| Component | GO:0005730 | nucleolus |
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.32 | 0.42 |
| Trophozoite | expressed | 1.21 | 0.40 |
| Schizont | expressed | 0.43 | 0.73 |
| Gametocyte | expressed | 0.65 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1419700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.131 | MFS: -3.132 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILQ3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102747
Most Similar Human Ortholog: E5RJT0
TM-align score: 0.78 | RMSD: 3.27
Seq Identity: 0.18 | Length: 230 / 509
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000147677 | eukaryotic translation initiation factor 3 subunit H |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 29 | 15 | 32 |
| disruptive | 26 | 62 | 27 | 79 |
| missense | 12 | 29 | 17 | 53 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 52 | 20 | 37 |
| disruptive | 44 | 150 | 53 | 135 |
| missense | 16 | 78 | 37 | 70 |
PlasmoDB Total SNPs: 189
Non-coding: 119 | Synonymous: 34 | Nonsynonymous: 35 | Stop Codon: 1
Protein Length: 509 | Molecular Weight (kDa): 59.693
UniProt ID(s): Q8ILQ3
PDB ID(s): None
Isoelectric Point: 4.59
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31390575 | Landscape of the Plasmodium Interactome Reveals Both Conserved andSpecies-Specific Functionality. | Hillier C, Pardo M, ..., Choudhary JS | 10.1016/j.celrep.2019.07.019 |