Product Description: YTH domain-containing protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005654 | nucleoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:1990247 | N6-methyladenosine-containing RNA binding |
| Function | GO:0003729 | mRNA binding |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
| Process | GO:0048024 | regulation of mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.34 | 0.83 |
| Trophozoite | not expressed | 0.17 | 0.89 |
| Schizont | not expressed | 0.09 | 0.94 |
| Gametocyte | not expressed | 0.22 | 0.86 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1419900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.119 | MFS: -2.98 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILQ1
"Best" AlphaFill ligand hit: 6MD (n-methyladenosine, Local RMSD=0.16) with 4RDN (Global RMSD=1.96)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 17 | 10 | 40 |
| disruptive | 4 | 29 | 31 | 71 |
| missense | 3 | 25 | 29 | 59 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 42 | 20 | 41 |
| disruptive | 7 | 103 | 61 | 133 |
| missense | 5 | 86 | 54 | 94 |
PlasmoDB Total SNPs: 75
Non-coding: 57 | Synonymous: 14 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 572 | Molecular Weight (kDa): 67.167
UniProt ID(s): Q8ILQ1
PDB ID(s): None
Isoelectric Point: 9.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007275 | YTH domain |
| PFam | PF04146 | YTH domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 31384004 | Transcriptome-wide dynamics of extensive m(6)A mRNA methylation during Plasmodiumfalciparum blood-stage development. | Baumgarten S, Bryant JM, ..., Scherf A | 10.1038/s41564-019-0521-7 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 32930954 | (1)H, (13)C and (15)N resonance assignment of the YTH domain of YTHDC2 | He F, Endo R, ..., Muto Y | 10.1007/s12104-020-09974-3 |
| 9535662 | Coupling termination of transcription to messenger RNA maturation in yeast | Birse CE, Minvielle-Sebastia L, ..., Proudfoot NJ | 10.1126/science.280.5361.298 |
| 9224719 | The 30-kD subunit of mammalian cleavage and polyadenylation specificity factorand its yeast homolog are RNA-binding zinc finger proteins | Barabino SM, Hubner W, ..., Keller W | 10.1101/gad.11.13.1703 |
| 34324585 | m6A RNA methylation facilitates pre-mRNA 3'-end formation and is essential forviability of Toxoplasma gondii | Holmes MJ, Padgett LR, Bastos MS, Sullivan WJ Jr | 10.1371/journal.ppat.1009335 |
| 24206186 | A novel protein, Pho92, has a conserved YTH domain and regulates phosphatemetabolism by decreasing the mRNA stability of PHO4 in Saccharomyces cerevisiae | Kang HJ, Jeong SJ, ..., Yun CW | 10.1042/BJ20130862 |
| 38316392 | Reading the epitranscriptome of the human malaria parasite | Govindaraju G, Rajavelu A | 10.1016/j.bj.2024.100703 |
| 10523662 | Pta1, a component of yeast CF II, is required for both cleavage and poly(A)addition of mRNA precursor | Zhao J, Kessler M, ..., Moore C | 10.1128/MCB.19.11.7733 |