Product Description: splicing factor 3B subunit 4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005686 | U2 snRNP |
| Component | GO:1990904 | ribonucleoprotein complex |
| Component | GO:0005681 | spliceosomal complex |
| Function | GO:0003723 | RNA binding |
| Process | GO:0008380 | RNA splicing |
| Process | GO:0000375 | RNA splicing, via transesterification reactions |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.18 | 0.91 |
| Trophozoite | expressed | 0.22 | 0.86 |
| Schizont | expressed | 0.06 | 0.95 |
| Gametocyte | expressed | 0.26 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1420000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.728 | MFS: -2.338 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1023200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1023200)
Modification: Disrupted | RMgm-2827
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILQ0
"Best" AlphaFill ligand hit: M2M (1-methoxy-2-(2-methoxyethoxy)ethane, Local RMSD=0.49) with 4ED5 (Global RMSD=6.42)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P11940 | Polyadenylate-binding protein 1 | Homo sapiens | OrthoDB | MLS000030667MLS000074721MLS000074731MLS000029721... |
Ortholog Group (OrthoMCL): OG6_102421
Most Similar Human Ortholog: Q5SZ64
TM-align score: 0.56 | RMSD: 2.81
Seq Identity: 0.53 | Length: 118 / 484
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000143368 | splicing factor 3b subunit 4 |
Protein Length: 484 | Molecular Weight (kDa): 53.723
UniProt ID(s): Q8ILQ0
PDB ID(s): None
Isoelectric Point: 5.38
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR034158 | SF3B4, RNA recognition motif 1 |
| InterPro | IPR034159 | SF3B4, RNA recognition motif 2 |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 20 | 17 | 32 |
| disruptive | 17 | 52 | 31 | 91 |
| missense | 8 | 33 | 21 | 52 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 51 | 25 | 28 |
| disruptive | 25 | 120 | 45 | 155 |
| missense | 13 | 76 | 31 | 80 |
PlasmoDB Total SNPs: 97
Non-coding: 45 | Synonymous: 34 | Nonsynonymous: 18 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |