PF3D7_1420100

Genome location: Pf3D7_14_v3:831,758..837,178(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.03	0.98
Schizont	possibly expressed	0.05	0.97
Gametocyte	expressed	0.35	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1420100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.997 | MFS: -2.674 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILP9

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=2.30) with 3DRW (Global RMSD=20.87)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_176188

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	58	45	93
disruptive	53	228	113	299
missense	34	193	102	258

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	25	138	58	113
disruptive	118	424	202	386
missense	79	347	181	293

PlasmoDB Total SNPs: 290

Non-coding: 137 | Synonymous: 79 | Nonsynonymous: 74 | Stop Codon: 0

Protein Information

Protein Length: 1449 | Molecular Weight (kDa): 170.439

UniProt ID(s): Q8ILP9

PDB ID(s): None

Isoelectric Point: 6.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR025677	OST-HTH associated domain
PFam	PF14418	OST-HTH associated domain
Superfamily	N/A	N/A