Product Description: myosin-specific chaperone UNC, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Process | GO:0006457 | protein folding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.31 | 0.81 |
| Schizont | expressed | 1.36 | 0.38 |
| Gametocyte | expressed | 0.35 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1420200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -3.07 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILP8
"Best" AlphaFill ligand hit: UMP (2'-deoxyuridine 5'-monophosphate, Local RMSD=1.58) with 7S01 (Global RMSD=18.44)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103191
Most Similar Human Ortholog: Q8IWX7
TM-align score: 0.55 | RMSD: 6.01
Seq Identity: 0.13 | Length: 636 / 1245
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000140553 | unc-45 myosin chaperone A |
| ENSG00000141161 | unc-45 myosin chaperone B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 66 | 29 | 69 |
| disruptive | 37 | 122 | 87 | 199 |
| missense | 22 | 110 | 83 | 175 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 122 | 44 | 86 |
| disruptive | 66 | 301 | 148 | 349 |
| missense | 38 | 253 | 120 | 261 |
PlasmoDB Total SNPs: 134
Non-coding: 39 | Synonymous: 59 | Nonsynonymous: 36 | Stop Codon: 0
Protein Length: 1245 | Molecular Weight (kDa): 148.025
UniProt ID(s): Q8ILP8
PDB ID(s): None
Isoelectric Point: 6.97
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR019734 | Tetratricopeptide repeat |
| PFam | PF13181 | Tetratricopeptide repeat |
| Superfamily | SSF48371 | Armadillo-type fold |
| Superfamily | SSF48452 | Tetratricopeptide-like helical domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 28593938 | Myosin-dependent cell-cell communication controls synchronicity of division inacute and chronic stages of Toxoplasma gondii. | Frenal K, Jacot D, ..., Soldati-Favre D | 10.1038/ncomms15710 |
| 38432292 | High-resolution epitope mapping of commercial antibodies to ANCA antigens byyeast surface display | Poulton JS, Lamba S, ..., Falk R | 10.1016/j.jim.2024.113654 |