Product Description: DNL-type zinc finger protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005759 | mitochondrial matrix |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0051087 | chaperone binding |
| Process | GO:0006457 | protein folding |
| Process | GO:0030150 | protein import into mitochondrial matrix |
| Process | GO:0050821 | protein stabilization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.36 | 0.82 |
| Trophozoite | not expressed | 0.15 | 0.91 |
| Schizont | possibly expressed | 0.21 | 0.86 |
| Gametocyte | not expressed | 0.18 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1420300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.126 | MFS: -3.001 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILP7
"Best" AlphaFill ligand hit: FMN (flavin mononucleotide, Local RMSD=5.99) with 3FJO (Global RMSD=18.29)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103202
Most Similar Human Ortholog: Q5SXM8
TM-align score: 0.45 | RMSD: 3.86
Seq Identity: 0.35 | Length: 105 / 302
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000213221 | DNL-type zinc finger |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 12 | 12 | 17 |
| disruptive | 14 | 57 | 18 | 54 |
| missense | 4 | 40 | 16 | 37 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 36 | 13 | 14 |
| disruptive | 34 | 100 | 40 | 96 |
| missense | 12 | 66 | 30 | 66 |
PlasmoDB Total SNPs: 87
Non-coding: 34 | Synonymous: 38 | Nonsynonymous: 15 | Stop Codon: 0
Protein Length: 302 | Molecular Weight (kDa): 35.251
UniProt ID(s): Q8ILP7
PDB ID(s): None
Isoelectric Point: 8.21
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007853 | Zinc finger, DNL-type |
| InterPro | IPR024158 | Mitochondrial import protein TIM15 |
| PFam | PF05180 | Zinc finger, DNL-type |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 27253881 | Plasmodium falciparum Hep1 Is Required to Prevent the Self Aggregation ofPfHsp70-3. | Nyakundi DO, Vuko LA, ..., Boshoff A | 10.1371/journal.pone.0156446 |