PF3D7_1420500

Genome location: Pf3D7_14_v3:849,819..853,349(-)

Genome classification: Core

Function and Localization

Product Description: protein GPR89, putative

SignalP Peptide: N/A

# Transmembrane Domains: 9

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.06	0.97
Trophozoite	not expressed	0.05	0.97
Schizont	not expressed	0.03	0.98
Gametocyte	possibly expressed	0.31	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1420500

Resistome Missense Mutations: T96S

Resistome Compounds with Missense Mutations: BCH070

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.98 | MFS: -0.886 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A1F3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532468

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	42	29	58
disruptive	25	99	65	120
missense	19	81	58	103

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	85	48	76
disruptive	44	193	112	209
missense	28	146	94	152

PlasmoDB Total SNPs: 158

Non-coding: 0 | Synonymous: 111 | Nonsynonymous: 47 | Stop Codon: 0

Protein Information

Protein Length: 1176 | Molecular Weight (kDa): 141.112

UniProt ID(s): A0A144A1F3

PDB ID(s): None

Isoelectric Point: 9.41

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR015672	The Golgi pH regulator/GPCR-type G protein
InterPro	IPR022535	Golgi pH regulator, conserved domain
InterPro	IPR025969	Abscisic acid G-protein coupled receptor-like domain
PFam	PF12430	Abscisic acid G-protein coupled receptor-like domain
PFam	PF12537	Golgi pH regulator, conserved domain
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097