Product Description: pantothenate kinase 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.1.33 (Pantothenate kinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0071889 | 14-3-3 protein binding |
| Function | GO:0004594 | pantothenate kinase activity |
| Function | GO:0005515 | protein binding |
| Process | GO:0015937 | coenzyme A biosynthetic process |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.23 | 0.89 |
| Trophozoite | expressed | 0.90 | 0.52 |
| Schizont | expressed | 0.16 | 0.90 |
| Gametocyte | not expressed | 0.23 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1420600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.176 | MFS: -2.769 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1022600)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1022600)
Modification: Disrupted | RMgm-4085
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILP4
"Best" AlphaFill ligand hit: PAZ (n-[(2r)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanine, Local RMSD=0.29) with 5KPZ (Global RMSD=4.34)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.1.33 | pantothenate kinase | ATPADPCoAAMPEDTANH4+HgCl2AlCl3GW5074citrateMCC-555neomycin... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q8ILP4 | Pantothenate kinase 1, putative | HOGENOM, OMA, OrthoDB, OrthoMCL, OrthoMCL BLAST | CHEMBL4167606 | |
| Q9H999 | Pantothenate kinase 3 | OrthoDB | CHEMBL3410244CHEMBL3410245CHEMBL3410246CHEMBL3410247... | |
| Q8TE04 | Pantothenate kinase 1 | OrthoDB | CHEMBL1555019CHEMBL3410398CHEMBL3410400CHEMBL3410248... | |
| Q9BZ23 | Pantothenate kinase 2, mitochondrial | OrthoDB | CHEMBL3410246 |
Ortholog Group (OrthoMCL): OG6_100565
Most Similar Human Ortholog: V9GYH1
TM-align score: 0.80 | RMSD: 2.60
Seq Identity: 0.19 | Length: 113 / 519
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000120137 | pantothenate kinase 3 |
| ENSG00000125779 | pantothenate kinase 2 |
| ENSG00000152782 | pantothenate kinase 1 |
| ENSG00000157881 | pantothenate kinase 4 (inactive) |
| ENSG00000273494 | pantothenate kinase 4 (inactive) |
Protein Length: 519 | Molecular Weight (kDa): 59.916
UniProt ID(s): Q8ILP4
PDB ID(s): None
Isoelectric Point: 7.86
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004567 | Type II pantothenate kinase |
| InterPro | IPR043129 | ATPase, nucleotide binding domain |
| PFam | PF03630 | Type II pantothenate kinase |
| Superfamily | SSF53067 | ATPase, nucleotide binding domain |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 34 | 12 | 36 |
| disruptive | 22 | 58 | 43 | 102 |
| missense | 18 | 52 | 39 | 92 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 54 | 19 | 41 |
| disruptive | 41 | 160 | 87 | 141 |
| missense | 32 | 127 | 73 | 101 |
PlasmoDB Total SNPs: 204
Non-coding: 141 | Synonymous: 33 | Nonsynonymous: 29 | Stop Codon: 1
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 29233590 | Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodiumfalciparum pantothenate kinase and inhibit parasite proliferation. | Spry C, Sewell AL, ..., Saliba KJ | 10.1016/j.ejmech.2017.08.050 |
| 33768012 | Characterization of Plasmodium falciparum Pantothenate Kinase and Identificationof Its Inhibitors From Natural Products. | Nurkanto A, Jeelani G, ..., Nozaki T | 10.3389/fcimb.2021.639065 |
| 34324601 | A novel heteromeric pantothenate kinase complex in apicomplexan parasites. | Tjhin ET, Howieson VM, ..., Saliba KJ | 10.1371/journal.ppat.1009797 |