PF3D7_1420800

Genome location: Pf3D7_14_v3:863,623..864,820(-)

Genome classification: Core

Function and Localization

Product Description: dynein light chain, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005930	axoneme
Component	GO:0005737	cytoplasm
Function	GO:0045504	dynein heavy chain binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.12	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1420800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.209 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1038500)

Relative Growth Rate: 1.08 ± 0.13
Confidence: 5.49

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILP2

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=6.25) with 7VHV (Global RMSD=17.24)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103386

Most Similar Human Ortholog: A0A499FIY3

TM-align score: 0.61 | RMSD: 4.30

Seq Identity: 0.18 | Length: 214 / 257

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000163879	dynein axonemal light intermediate chain 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	15	6	19
disruptive	0	26	7	28
missense	0	26	6	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	25	9	17
disruptive	6	39	19	58
missense	3	36	17	45

PlasmoDB Total SNPs: 61

Non-coding: 52 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 2

Protein Information

Protein Length: 257 | Molecular Weight (kDa): 30.842

UniProt ID(s): Q8ILP2

PDB ID(s): None

Isoelectric Point: 9.36

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR019347	Axonemal dynein light chain
PFam	PF10211	Axonemal dynein light chain
Superfamily	N/A	N/A