PF3D7_1421000 (DIX)

Genome location: Pf3D7_14_v3:867,794..868,957(-)

Genome classification: Core

Function and Localization

Product Description: DIX domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.09	0.95
Trophozoite	not expressed	0.11	0.93
Schizont	possibly expressed	0.03	0.98
Gametocyte	expressed	0.31	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1421000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.876 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1022200)

Relative Growth Rate: 0.16 ± 0.25
Confidence: 4.14

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILP0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119578

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	7	5	8
disruptive	2	16	8	32
missense	2	15	8	30

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	17	8	9
disruptive	6	38	20	48
missense	5	33	17	36

PlasmoDB Total SNPs: 93

Non-coding: 76 | Synonymous: 12 | Nonsynonymous: 4 | Stop Codon: 1

Protein Information

Protein Length: 177 | Molecular Weight (kDa): 20.734

UniProt ID(s): Q8ILP0

PDB ID(s): None

Isoelectric Point: 7.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001158	DIX domain
InterPro	IPR029071	Ubiquitin-like domain superfamily
PFam	PF00778	DIX domain
Superfamily	SSF54236	Ubiquitin-like domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
38257898	Coinfection with Leishmania infantum and Toxoplasma gondii in Domestic Cats froma Region with a High Prevalence of Feline Immunodeficiency Virus	Bezerra JAB, Haisi A, ..., Azevedo SS	10.3390/microorganisms12010071