PF3D7_1421100

Genome location: Pf3D7_14_v3:870,397..875,176(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.87	0.62
Trophozoite	possibly expressed	0.26	0.84
Schizont	possibly expressed	0.19	0.88
Gametocyte	expressed	0.20	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1421100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.715 | #Insertions: 8

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1022100)

Relative Growth Rate: 0.93 ± 0.09
Confidence: 6.10

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1022100)

Modification: Disrupted | RMgm-2822

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILN9

"Best" AlphaFill ligand hit: B3P (2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol, Local RMSD=0.82) with 5NFV (Global RMSD=23.74)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532705

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	40	36	53
disruptive	77	174	92	209
missense	51	145	77	168

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	98	59	70
disruptive	142	370	160	372
missense	93	281	117	219

PlasmoDB Total SNPs: 340

Non-coding: 129 | Synonymous: 85 | Nonsynonymous: 126 | Stop Codon: 0

Protein Information

Protein Length: 1253 | Molecular Weight (kDa): 150.714

UniProt ID(s): Q8ILN9

PDB ID(s): None

Isoelectric Point: 6.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR016084	Haem oxygenase-like, multi-helical
PFam	N/A	N/A
Superfamily	SSF48613	Haem oxygenase-like, multi-helical