Product Description: 40S ribosomal protein S25
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.40 | 0.81 |
| Trophozoite | expressed | 0.58 | 0.67 |
| Schizont | expressed | 0.08 | 0.94 |
| Gametocyte | expressed | 0.22 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1421200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.846 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILN8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100950
Most Similar Human Ortholog: P62851
TM-align score: 0.72 | RMSD: 1.97
Seq Identity: 0.40 | Length: 83 / 105
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000118181 | ribosomal protein S25 |
| ENSG00000280831 | ribosomal protein S25 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 5 | 0 | 2 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 2 | 5 | 1 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 119
Non-coding: 111 | Synonymous: 6 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 105 | Molecular Weight (kDa): 11.664
UniProt ID(s): Q8ILN8
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 10.86
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004977 | Ribosomal protein S25 |
| PFam | PF03297 | Ribosomal protein S25 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33587312 | Lipopolysaccharide-regulated secretion of soluble and vesicle-based proteins froma panel of colorectal cancer cell lines | Garcia de Durango CR, Monteiro MN, ..., Jimenez CR | 10.1002/prca.201900119 |
| 37358794 | RNA sequencing reveals the mechanism of FTO in inhibiting inflammation andexcessive proliferation of lipopolysaccharide-induced human glomerular mesangialcells | Zhuang X, Liu T, ..., Gao J | 10.1007/s00210-023-02570-x |