PF3D7_1421300

Genome location: Pf3D7_14_v3:877,441..881,450(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.04	0.98
Trophozoite	possibly expressed	0.09	0.95
Schizont	possibly expressed	0.13	0.92
Gametocyte	expressed	0.74	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1421300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.639 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILN7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533158

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	42	34	64
disruptive	37	151	90	206
missense	24	122	79	163

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	105	47	78
disruptive	82	355	157	334
missense	44	266	128	193

PlasmoDB Total SNPs: 231

Non-coding: 133 | Synonymous: 64 | Nonsynonymous: 33 | Stop Codon: 1

Protein Information

Protein Length: 1016 | Molecular Weight (kDa): 122.988

UniProt ID(s): Q8ILN7

PDB ID(s): None

Isoelectric Point: 9.57

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A